Contributions to Nephrology - 156: Acute Kidney Injury

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Acute kidney injury is characterized by sudden changes in serum creatinine and urine output, affecting many ICU patients. Despite its prevalence, treatment options remain limited, and understanding of the condition is still developing. This volume features insights from an interdisciplinary panel of experts who explore various facets of the disorder, including pathophysiology, treatment, emerging biomarkers, and genetic polymorphisms. Contributions also address immunological concerns and the complications arising from acute kidney injury in patients with co-morbid conditions, presenting both foundational knowledge and the latest advancements. Key technical aspects of extracorporeal therapies, such as vascular access, anticoagulation, and fluid composition, are discussed alongside different renal support strategies, including intermittent dialysis, continuous therapies, and hybrid techniques. The text concludes with an overview of advanced extracorporeal organ support methods and their significance in managing sepsis and acute kidney injury within the broader context of multi-organ failure. This volume not only summarizes current knowledge and technology but also fosters a deeper understanding of pathogenesis and anticipates future developments, prompting a re-examination of fundamental assumptions about critical illness and acute kidney injury.