Pharmacokinetic-Pharmacodynamic Modeling and Simulation

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The book offers a comprehensive exploration of pharmacokinetic and pharmacodynamic modeling, emphasizing nonlinear mixed effects models. It employs a building block approach, progressing from individual-level models to more complex population-level models. The second edition introduces new chapters on Bayesian and generalized nonlinear mixed effects models, along with an extensive chapter on simulation. Real data examples enhance understanding, and various software tools are utilized for analysis. Aimed at pharmaceutical scientists, it also serves statisticians and mathematicians interested in advanced statistical modeling.