AAPS Introductions in the Pharmaceutical Sciences - 13: Pharmaceutical Process Engineering and Scale-up Principles

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This book provides a comprehensive overview of the unit operations in manufacturing solid and liquid dosage forms, along with the scale-up of each operation. It serves as a valuable resource for pharmaceutical professionals and researchers aiming to deepen their understanding of the manufacturing process. The content is organized into four sections. Section I introduces the basic principles of manufacturing solid and liquid dosage forms. Section II delves into the unit operations for solid dosage production, such as mixing, granulation, drying, compression, coating, and size reduction, supported by case studies that offer practical insights into scale-up principles. Section III addresses the manufacturing and scale-up of liquid formulations, discussing mixing, filtration, and the complexities of scaling liquid mixing processes, along with the associated challenges and opportunities. Finally, Section IV presents two chapters on advanced drug delivery systems, covering the manufacturing and scale-up of nanoparticles and biotechnology-derived products, providing insights into innovative drug delivery development and its challenges. Overall, this book is an essential guide for those seeking a deeper understanding of the manufacturing process, enriched with case studies and practical examples that illustrate the scale-up challenges and opportunities in the pharmaceutical industry.