Onkologisches Kolloquium - 2: Die lokoregionale Tumortherapie

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This comprehensive work explores various aspects of locoregional therapy, focusing on its limitations and future applications, particularly with Mitoxantrone. It begins with foundational methodological concepts and progresses through pharmacokinetics, detailing the intraperitoneal administration of Mitoxantrone and its effects in advanced ovarian cancer with ascites. The text includes a phase I study examining pharmacokinetics and various techniques for intraperitoneal chemotherapy, emphasizing catheter techniques and treatment indications. Further discussions cover the pharmacokinetics of 5-Fluorouracil and Mitoxantrone during isolated liver perfusion, as well as intrapleural applications of Mitoxantrone. Methodological approaches to optimize concentration-time factors in regional chemotherapy are also presented. Clinical applications are highlighted, including intratumoral Mitoxantrone instillation combined with radiation therapy for advanced head and neck tumors and the role of locoregional chemotherapy in advanced breast cancer. The work concludes with insights into indications and techniques of locoregional chemotherapy in urology, offering a thorough examination of current practices and future directions in cancer treatment.