Blame! presents the dark side of transhumanism, where human beings unencumbered by humanity readily use technology to remake themselves into walking monstrosities, gaining incredible abilities even as they doom themselves to extinction. In Blame! 's world, the Singularity arrived a long time ago, but rather than usher in a new golden age, it's left nothing but decimation in its wake. - Opus
The Administration contacts Kyrii and Cibo, encouraging them to keep searching for the Net Terminal Gene which will stop the City from its intractable, chaotic growth. The Admin also warns them of the autonomous Safeguards, vicious entities that attempt to kill off any humans who access the Netsphere without the required Net Terminal Gene. Kyrii is attacked, and a group of humans who have settled on the outskirts of Toha Heavy Industries comes to his aid. Kyrii awakens with a newfound ability to read his surroundings, which allows him mere seconds to fend off an attacker lurking among the humans settlement. In the ensuing battle, Cibo makes a heavy sacrifice, but not before learning a startling truth about her traveling companion...