This book discusses the mechanisms underlying the breakdown of articular cartilage, diarthrodial joint failure, the synovium, and neuromuscular system. A section of the book is devoted to pharmacologic modification of tissue damage in OA. Optimal management of OA requires a comprehensive program involving drugs and nommeidcal components, and is discussed at length. Chapters include definition of OA, epidemiology, pathology, pathogenesis, clinical features, pitfalls in diagnosis of OA, synovial fluid analysis, pharmacologic and nonpharmacologic therapies, and strategy for management of OA
