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Více o knize
Focusing on the synthesis and evaluation of stable lipoxin analogues, the thesis presents groundbreaking work by Colm Duffy, who successfully created a pyridine-containing LXA4 analogue in enantiomerically pure form for the first time. The study reveals that both epimers suppress key cytokines linked to inflammatory diseases, with the (R)-epimer demonstrating superior efficacy. Additionally, Duffy developed a thiophene-containing analogue, showing promising biological activity, which has sparked further research into synthesizing more heteroaromatic analogues for evaluation.
Nákup knihy
Heteroaromatic Lipoxin A4 Analogues, Colm Duffy
- Jazyk
- Rok vydání
- 2012
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Doručení
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- Titul
- Heteroaromatic Lipoxin A4 Analogues
- Podtitul
- Synthesis and Biological Evaluation
- Jazyk
- anglicky
- Autoři
- Colm Duffy
- Vydavatel
- Springer Berlin Heidelberg
- Rok vydání
- 2012
- Vazba
- pevná
- Počet stran
- 152
- ISBN13
- 9783642246319
- Série
- Springer Theses
- Štítky
- Naučná literatura
- Anotace
- Focusing on the synthesis and evaluation of stable lipoxin analogues, the thesis presents groundbreaking work by Colm Duffy, who successfully created a pyridine-containing LXA4 analogue in enantiomerically pure form for the first time. The study reveals that both epimers suppress key cytokines linked to inflammatory diseases, with the (R)-epimer demonstrating superior efficacy. Additionally, Duffy developed a thiophene-containing analogue, showing promising biological activity, which has sparked further research into synthesizing more heteroaromatic analogues for evaluation.
