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Heteroaromatic Lipoxin A4 Analogues

Synthesis and Biological Evaluation

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  • 152 stránek
  • 6 hodin čtení

Více o knize

Focusing on the synthesis and evaluation of stable lipoxin analogues, the thesis presents groundbreaking work by Colm Duffy, who successfully created a pyridine-containing LXA4 analogue in enantiomerically pure form for the first time. The study reveals that both epimers suppress key cytokines linked to inflammatory diseases, with the (R)-epimer demonstrating superior efficacy. Additionally, Duffy developed a thiophene-containing analogue, showing promising biological activity, which has sparked further research into synthesizing more heteroaromatic analogues for evaluation.

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Heteroaromatic Lipoxin A4 Analogues, Colm Duffy

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Rok vydání
2012
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