Tato série sleduje neslavného žoldáka s nadměrným ústním projevem, který se potýká s vlastní morálkou a často chaotickými následky svých činů. S humorem, akcí a občasnou dávkou tragédie zkoumá složitost dobra a zla prostřednictvím jedné z nejoblíbenějších anti-hrdinských postav. Je to jízda plná překvapení, kde se smrtící schopnosti snoubí s nečekanou vnitřní zpovědí.
DEADPOOL KILLS CABLE! You heard that right. No more being a hero - Deadpool is a wanted man, and he's back to doing what he does best: killing people. What better way to show you're serious about going bad than killing your best friend? Get ready for a brutal fight. Collecting Despicable Deadpool 287-291.
Deadpool has a lot of unfinished business in his inbox, and he's determined to take care of it before...any sort of bad and permanentish thing happens to him. Revenge on Stevil Rogers? Settling things with Rogue? Oh, and doesn't he still need to kill a few more folks? It's time to get Wade's affairs in order. You know, just in case... COLLECTING: DESPICABLE DEADPOOL 292-296
Deadpool has killed the Marvel Universe (in fact, more than once)... now it's time for the MU to return the favour. Collecting Despicable Deadpool 297-300 (subject to change).