Redox-Active Therapeutics

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This essential volume comprehensively discusses redox-active therapeutics, emphasizing their molecular design, mechanisms, pharmacology, and medicinal aspects. The initial section covers the chemistry and biology of redox-active drugs, including an overview of redox pathways in cancer and the medical implications of these drugs, requiring minimal prior knowledge. Subsequent sections delve into specialized topics such as central nervous system injuries, neurodegenerative diseases, pain, radiation injury, and neglected diseases like leishmaniasis. It explores major classes of redox-active experimental therapeutics, including porphyrins, salens, nitrones, and particularly metal-containing drugs (e.g., Mn, Fe, Cu, Zn, Sb), either as standalone compounds or in formulations with nanomaterials and quantum dots. Numerous illustrations, tables, and figures enhance the text, along with extensive references to relevant literature. This work is a valuable addition to the Oxidative Stress in Applied Basic Research and Clinical Practice series by Springer. It is essential reading for researchers, clinicians, and graduate students interested in the Redoxome—the organism's redox network—as a new frontier in drug design, redox biology, and medicine.