James A. Roth Knihy

The field of microbial pathogenesis has expanded rapidly over the past decade. Literally thousands of research papers have been published and new specialty journals on microbial pathogenesis have appeared, giving rise to the need for a text that reviews the entire field of bacterial virulence mechanisms and summarizes the major advances. The third edition of this best-selling volume provides an overview of current knowledge of the wide variety of mechanisms used by bacterial pathogens in establishing infection, producing disease, and persisting in the host. Internationally recognized authorities in the field review bacterial invasion, colonization, and survival; bacterial evasion of host defense mechanisms; bacterial effects on host cell function; and identification, regulation, and transfer of virulence genes. The final chapter presents an interesting examination of new methods for studying virulence mechanisms in the complex in vivo environment, a major development in studies of bacterial pathogenicity. The overall emphasis is on understanding the mechanisms of host-pathogen interactions rather than on focusing on specific research approaches. Virulence Mechanisms of Bacterial Pathogens, 3rd Edition is valuable reading for molecular biologists, infectious disease specialists, researchers, industry scientists, faculty, and graduate students.

Transboundary animal diseases (TADs) are a major threat to livestock. They are highly contagious or transmissible, and they have the potential to cause high morbidity and mortality in both susceptible animal populations and humans. In addition, not only are TADs detrimental to national economies, they are also a serious threat to world food security. This volume presents the proceedings of an international workshop on Vaccines and Diagnostics for Transboundary Animal Diseases that was held in Ames (Iowa, USA) in 2012. Experts and scientists from academia, industry and government reviewed the current status of vaccines and diagnostics for high priority TADs, decision-making and regulatory processes for veterinary biologics, and the roles and responsibilities of government agencies. The discussions also addressed achievements and gaps in vaccine and diagnostics development for 11 important TADs as well as the translation of research findings into licensed novel vaccines and diagnostics for high-priority TADs.