Domenico Ribatti Knihy

Focusing on the interplay between immune cells and angiogenesis, this book analyzes how both innate and adaptive immune components contribute to endothelial cell behavior, influencing inflammation and tumor growth. It explores the historical context linking chronic inflammation to cancer, highlighting the role of leukocytes in tumors. The text also discusses the balance of pro- and anti-angiogenic factors, suggesting potential pharmacological applications of immune cells as anti-angiogenic agents. It serves as a resource for researchers and graduate students in the field.

The book presents recent advances in the field of angiogenesis and antiangiogenesis. Starting with the hypothesis of Judah Folkman that tumor growth is angiogenesis dependent, this area of research now has a solid scientific foundation. Tumor growth, metastasis, progression, dormancy and apoptosis depend on angiogenesis: several clinical studies have shown a positive correlation between the number of vessels in the tumor, metastasis formation and disease prognosis. A number of approaches have been developed to inhibit tumor angiogenesis, and numerous compounds discovered that inhibit angiogenesis, but only a few of them proved effective in vivo and only a couple of agents were able to induce tumor regression. These and other related developments described in the book should prove to be of interest to a large number of readers wishing to keep abreast with the latest developments in the field.

Focusing on angiogenesis's pivotal role in tumor progression and metastasis, this book delves into innovative anti-angiogenesis molecules currently being utilized against hematological malignancies, including leukemia and lymphoma. It highlights the latest advancements in treatment strategies, providing insights into the therapeutic potential of these molecules in combating cancer.

Exploring pivotal advancements in the field of immunology, this collection showcases significant research and discoveries that have shaped our understanding of the immune system. It highlights key papers that contributed to the development of immunological concepts and therapies, providing insights into the evolution of the discipline. The work serves as a valuable resource for both students and professionals, illustrating the historical context and ongoing impact of immunological research on health and disease management.

Exploring the intricate relationship between tumors and their surrounding microenvironment, this book delves into how various factors influence tumor growth and progression. It examines cellular interactions, signaling pathways, and the role of immune cells, providing a comprehensive understanding of the tumor microenvironment's impact on cancer biology. By integrating cutting-edge research and insights, it aims to highlight potential therapeutic strategies targeting these interactions to inhibit tumor expansion, making it essential for researchers and clinicians in oncology.

This book provides a comprehensive overview of in vivo models used to study angiogenesis, the process of new blood vessel formation. It covers various experimental techniques and methodologies, offering insights into their applications in research and potential therapeutic implications. The text emphasizes the importance of these models in understanding vascular biology and disease mechanisms, making it a valuable resource for researchers and practitioners in the fields of biomedicine and pharmacology.

Focusing on the historical development of immune surveillance against tumors, this book examines the evolution of immunotherapy and the concept of immunoediting. It presents evidence supporting and challenging the immune surveillance theory, highlighting the immune system's critical role in detecting tumors. The text discusses tumor cell strategies to evade immune attacks, supported by findings from animal models and clinical cases. It also addresses the paradox of cancer development in individuals with normal immune function, illustrating the complexity of tumor immunity.

Focusing on tumor blood vessel abnormalities, this book identifies specific tumor endothelial markers and chromosomal irregularities. It explores the potential of these markers for targeted drug delivery to the tumor microvasculature, offering insights into innovative therapeutic strategies in cancer treatment.

The chick embryo chorioallantoic membrane (CAM) serves as a vital platform for studying angiogenesis due to its rich vascular network and accessibility. It enables researchers to explore both pro-angiogenic and anti-angiogenic agents, as well as the mechanisms behind tissue graft survival through vascular integration. Particularly valuable for tumor studies, the CAM allows for the observation of tumor growth dynamics and the effects of angiogenic factors, while also facilitating the investigation of tumor cell invasion into surrounding tissues.

Focusing on the groundbreaking hypothesis by J. Folkman in 1971 regarding the dependence of tumor growth on angiogenesis, this book explores the evolution of this concept leading to the FDA's approval of the first angiogenesis inhibitor in 2004. It compiles significant literature that highlights the antiangiogenic strategies in cancer treatment, providing insights into the scientific advancements and implications for future therapies in oncology.