Jürgen Grote Knihy

Im Mittelpunkt des 5. internationalen Westerländer Gesprächs, zu dem namhafte Wissenschaftler aus klinischen wie theoretischen Fächern der Medizin gekommen waren, standen aktuelle Probleme der Durchblutungsregulation, des Atemgaswechsels und des Stoffwechsels. Einen weiteren Schwerpunkt bildeten die neuen Befunde zur Einstellung des Spannungszustandes der Gefäßmuskulatur durch Stoffwechselprodukte der Gefäßinnenwände und ihre Bedeutung für das Verständnis der Funktions-zusammenhänge bei der Anpassung der Organdurchblutung an den momentanen Bedarf. Ergänzend wurde über wichtige Ergebnisse von Untersuchungen der Gewebsatmung und des Stoffwechsels bei Ischämie und Hypoxie sowie der Möglichkeiten einer verbesserten Organprotektion berichtet. Alle Beiträge geben deshalb einen guten Überblick über den aktuellen Stand der Forschung in Deutschland auf den genannten Gebieten.

The text explores various aspects of pulmonary gas exchange and regulation, focusing on the physiological and biochemical processes involved. It discusses how extreme temperatures affect air conditioning in the lungs and examines advanced imaging techniques for assessing regional gas content. The diffusion limitations in gas mixing within the lungs are analyzed, alongside the roles of carbonic anhydrases in CO2 exchange. The pulmonary diffusing capacity is evaluated through studies using labeled carbon dioxide, while the CO2 binding curve in human blood is examined in relation to hemoglobin oxygenation. Computer-assisted simulations of acid-base balance are also addressed, alongside ion distribution studies in carp. Kinetics of O2 exchange in erythrocytes are measured using the "Stopped Flow" technique, and O2 saturation times in lung capillaries are investigated. The relationship between hemoglobin oxygen affinity and physical exercise is highlighted, as well as the production site of erythropoietin in the kidneys. Clinical implications of airway obstruction and the significance of ventilation, perfusion, and diffusion distribution disorders are discussed, along with the evolving understanding of pneumonia as a disease. The regulation of respiration is examined through animal and human studies, exploring the differentiation of respiratory rhythmogenesis and the significance of post-inspiration, as well as the potential ex

E. BETZ discusses the permeability of the endothelium and its modifiability. J. FINGERLE explores endothelial cells in organ culture. H. SINZINGER examines the role of PGI2 formation in normal and pseudo-vessels concerning atherosclerosis. D. G. S. THILO-KÖRNER, F. LUTZ, and W. SCHAEG investigate the influence of bacterial toxins on human endothelial cells. J. GRÜNWALD focuses on the migration and proliferation of smooth muscle cells. D. RIEDIGER and H. WOLBERG address endothelial regeneration in micro-surgical vascular anastomoses. U. PEIPER and C.-F. VAHL analyze the kinetics of the fundamental contraction process in vascular musculature. U. POHL, R. BUSSE, and E. BASSENGE discuss the functional significance of the endothelium for the vasomotor function of large arteries. R. BUSSE et al. characterize the "endothelium-derived relaxant factor." G. SIEGEL studies the interaction between noradrenaline and calcium ions in vascular smooth muscle. C. STICK interprets pressure-flow relationships in the organ circulation. M. STEINMETZ and CH. WEISS present an improved device for measuring tissue perfusion. H. WEIGELT and H. H. DIETRICH examine local blood flow regulation in the capillary bed. S. NEES highlights recent aspects of adenosine-mediated coronary flow regulation. K. SCHRÖR and R. VERHEGGEN discuss the significance of platelet-derived thromboxane A2 and serotonin in coronary vasoconstriction. A. UNTERBERG et al. explore vaso