The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences.
This volume contains a comprehensive collection of methods for the isolation of platelet membranes, subcellular organelles, the cytoskeleton, and for the assay and purification of platelet receptors. Key Features * Platelets are cellular elements with the highest density of receptors per membrane surface area involved in binding of adhesive molecules, clotting, enzymes, and vasoactive amines * Platelets are essential for the arrest of bleeding and for formation of intravascular thrombi contributing to heart attacks, strokes, and disseminated intravascular coagulation, and are involved in immune complex disease * Platelets are useful for studying the processes of cell adhesion, neurotransmitter uptake, stimulus-response coupling, including signal transduction and secretion