Sildenafil

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This landmark drug has become the definitive therapy for erectile dysfunction (ED), stemming from significant breakthroughs in nitric oxide (NO) physiology and pharmacology. This reference book presents the latest information, including ongoing research on NO as an endothelium-derived relaxing factor (EDRF) and a neurotransmitter in erectile tissue. The development of sildenafil as an oral phosphodiesterase-5 (PDE5) inhibitor marked a successful transition from basic NO research to clinical therapy. The volume explores sildenafil's applications in both men and women, addressing the critical medical need for drug improvements in a competitive research environment. Readers will gain insights into clinical resistance to sildenafil and strategies to address treatment failures. Individual chapters cover clinical use, pharmacokinetics, pharmacodynamics, biochemistry, and cultural aspects, authored by leading experts in their fields. This comprehensive resource serves professionals in the pharmaceutical industry, physicians treating ED, biochemists, chemists, and pharmacologists, providing a detailed and current knowledge base on research activities and an excellent overview for further exploration of this compound class and its cultural significance.