Female sex and ER-alpha modulate cardiac ischaemic remodeling

The study explores the protective role of estrogen receptors (ER) in myocardial injury, highlighting significant differences between sexes. Utilizing a transgenic mouse model with cardiomyocyte-specific ER overexpression, findings reveal that while both genders exhibit increased left ventricular mass, only females show improved cardiac outcomes post-myocardial infarction. These benefits include reduced ventricular fibrosis, enhanced angiogenesis, and increased JNK phosphorylation, suggesting that targeting ER in female cardiomyocytes could offer therapeutic advantages in treating ischemic heart disease.