Female sex and ER-alpha modulate cardiac ischaemic remodeling
Cardiomyocyte-specific overexpression of estrogen receptor alpha provides cardioprotection in female mice
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Více o knize
The study explores the protective role of estrogen receptors (ER) in myocardial injury, highlighting significant differences between sexes. Utilizing a transgenic mouse model with cardiomyocyte-specific ER overexpression, findings reveal that while both genders exhibit increased left ventricular mass, only females show improved cardiac outcomes post-myocardial infarction. These benefits include reduced ventricular fibrosis, enhanced angiogenesis, and increased JNK phosphorylation, suggesting that targeting ER in female cardiomyocytes could offer therapeutic advantages in treating ischemic heart disease.
Nákup knihy
Female sex and ER-alpha modulate cardiac ischaemic remodeling, Xiang Zhang
- Jazyk
- Rok vydání
- 2017
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- (měkká)
Doručení
Platební metody
Navrhnout úpravu
- Titul
- Female sex and ER-alpha modulate cardiac ischaemic remodeling
- Podtitul
- Cardiomyocyte-specific overexpression of estrogen receptor alpha provides cardioprotection in female mice
- Jazyk
- anglicky
- Autoři
- Xiang Zhang
- Rok vydání
- 2017
- Vazba
- měkká
- Počet stran
- 92
- ISBN13
- 9783838151281
- Kategorie
- Zdraví / Medicína / Lékařství
- Anotace
- The study explores the protective role of estrogen receptors (ER) in myocardial injury, highlighting significant differences between sexes. Utilizing a transgenic mouse model with cardiomyocyte-specific ER overexpression, findings reveal that while both genders exhibit increased left ventricular mass, only females show improved cardiac outcomes post-myocardial infarction. These benefits include reduced ventricular fibrosis, enhanced angiogenesis, and increased JNK phosphorylation, suggesting that targeting ER in female cardiomyocytes could offer therapeutic advantages in treating ischemic heart disease.