Endosymbiotic Archaea and Mitochondrial Disease

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The book explores the implications of archaeal endosymbiosis on cellular metabolism, particularly its role in inducing the Warburg phenotype, characterized by increased glycolysis and mitochondrial dysfunction. It discusses how this process leads to anaerobic glycolysis and disrupts mitochondrial oxidative phosphorylation, evidenced by low serum coenzyme Q and ATP levels. Additionally, it connects archaeal-mediated mitochondrial disease to various health conditions, including schizophrenia, cancer, metabolic syndrome, autoimmune diseases, and neurodegeneration.