Footmarks of Innate Immunity in the Ovary and Cytokeratin-Positive Cells as Potential Dendritic Cell

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Innate immunity plays a crucial role in ovarian functions, acting alongside the endocrine system to regulate processes like follicular atresia, rupture, and corpus luteum regression through inflammation and tissue repair. The study identifies cytokeratin-positive (CK+) cells as a unique dendritic cell type involved in these processes. It explores their morphological characteristics in various animal ovaries, their regulatory roles under stress conditions, and implications for ovarian disorders. This innovative perspective may pave the way for new therapeutic strategies for conditions such as anovulation and luteal phase insufficiency.