Christiane Lindner Knihy

Die Forschung beleuchtet die Rolle von N-terminal verkürzten und pyroglutamyl-modifizierten Amyloid-Peptiden (A ) bei Alzheimer. Glutaminylzyklasen (QCs) sind entscheidend für die Modifikation dieser Peptide und stellen ein Ziel für die Wirkstoffentwicklung dar. Durch Experimente mit Drosophila melanogaster wurde die Funktion von QCs untersucht und der Inhibitor P150/03 getestet. Genanalysen identifizierten zwei QC-Gene, und transgene Drosophila-Linien wurden erstellt, um verschiedene A -Spezies zu exprimieren. Erste Ergebnisse zeigen, dass P150/03 die Konzentration von pyroGlu-A -Peptiden reduzieren kann.

The book "Sarah Ann Dobbs" describes the extraordinary life of a Victorian lady told by her autograph Album. Over 150 years old, the autograph Album of Sarah Dobbs containing beautifully handwritten poems, dating from 1862 to 1871, is a remarkable and fascinating document of the Victorian age. By steamship it made its way from Wales, UK, to the USA around 1868 as its owner Sarah Dobbs immigrated as one of the early pioneers to Kansas, USA. This book contains all Album entries, for better reading they were transcribed and where possible identified. The author also added a genealogy research, underlined by newspaper articles which were all transcribed, of Sarah Dobbs, her family and the family of her husband Henry Poolly Cooper. Before their immigration to the USA both of them lived in Chepstow, Monmouthshire, Wales, UK. Sarah Dobbs as innkeeper daughter of the White Hart Inn, Beaufort Square, Chepstow, Wales, UK.