Werner E. G. Müller Knihy

This book describes the discovery of molecules from unexploited extreme marine environments, and presents new approaches in marine genomics. It combines the current state of knowledge in marine genomics and advanced natural products’ chemistry to pursue the sustainable production of novel secondary metabolites (lead compounds), as well as pharmacologically active peptides/proteins, with antimicrobial, neuroprotective, anti-osteoporotic, anti-protozoan/anti-plasmodial, anti-ageing and immune-modulating effects. Further, it employs molecular-biology-based approaches and advanced chemical techniques to obtain and to select candidate compounds for pre-clinical and clinical studies.

This book summarizes the current understanding of inorganic polymers and their potential biomedical applications. Recently, these polymers have gained attention in nano-biomedicine, particularly in regenerative medicine and drug delivery, spurred by advancements in synthetic and analytical methods in nanotechnology. Notable examples include polysilicate/silica glass, such as biosilica and synthetic bioglass, and inorganic polyphosphate, which have demonstrated biomedical effects and have been tested in preclinical or clinical trials. Applications include bioglass for bone repair and tissue engineering, as well as the use of inorganic polyphosphates in food processing and dental care. While several biological and medicinal properties of these polymers have been identified, many have yet to be utilized in human treatments. Additionally, other inorganic polymers like polyarsenate and polyvanadate have only been minimally studied for their biomedical properties. The combination of inorganic polymers with organic polymeric molecules to create organic-inorganic hybrid materials offers new opportunities for developing materials with unique properties and diverse applications in nanomedicine.