Chromosome 12 aberrations in human solid tumors

Více o knize

This work explores the cytogenetic background and implications of chromosome 12 abnormalities across various tumors. It delves into specific conditions, such as pleomorphic adenomas and uterine leiomyomas, highlighting the role of chromosome 12 in their development. The cytogenetics of lipomas and well-differentiated liposarcomas are also examined, alongside breakpoints and recipient chromosomes in these tumors. The study of trisomy 12 in female genital tract tumors is included, as well as a comprehensive numerical analysis of carcinoma in situ and invasive germ cell tumors of the adult testis, utilizing interphase cytogenetics and immunohistochemistry. Molecular genetics related to chromosome 12 is discussed, with comparative gene mapping between human chromosome 12 and mouse chromosome 15. The work further investigates the molecular oncology of 12q13–15, gene analysis methods, and the development of cell lines from tumors exhibiting 12q13–15 aberrations. Additionally, it provides a fluorescence in situ hybridization inventory of chromosome 12 aberrations in human germ cell tumors and characterizes cell lines from a myxoid liposarcoma with specific genetic alterations. The amplification of certain loci in tumor cells and the analysis of solid tumors with recurrent breakpoints in chromosome 12q13–15 are also addressed. Lastly, it includes the isolation and characterization of cosmids mapping to human chromosome 12p.