The Chick Embryo Chorioallantoic Membrane in the Study of Angiogenesis and Metastasis

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The chick embryo chorioallantoic membrane (CAM) serves as a vital platform for studying angiogenesis due to its rich vascular network and accessibility. It enables researchers to explore both pro-angiogenic and anti-angiogenic agents, as well as the mechanisms behind tissue graft survival through vascular integration. Particularly valuable for tumor studies, the CAM allows for the observation of tumor growth dynamics and the effects of angiogenic factors, while also facilitating the investigation of tumor cell invasion into surrounding tissues.