High-Resolution Profiling of Protein-RNA Interactions

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Focusing on the study of RNA-binding proteins, this book explores the innovative 'protein occupancy profiling' technology that reveals how these proteins interact with mRNA sequences. It highlights the discovery that extensive regions in 3' UTRs are engaged by RNA-binding proteins, emphasizing the role of evolutionary conservation and negative selection in shaping these interactions. The comparative analysis of RBP-bound sequences promises to uncover significant biological insights, enhancing our understanding of gene regulation and RNA functionality.