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From food to medicine: process development and use of functionalized polyclonal antibodies from cow's milk for the treatment of infections caused by multi-resistant bacteria

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In this thesis, the process-technical prerequisites were achieved to provide new cow antibody-based therapeutic options for bacterial infections as substitutes for non-specific antibiotics. Microfiltration was investigated for the fractionation of antibodies from milk and a new scalable chromatography process for the isolation of IgG was developed. Specific polyclonal antibodies were induced by immunization of cows in milk, the products obtained were characterized and their efficacy demonstrated for the treatment of Clostridium difficile infection in an animal model.

Skladem máme celkem knihy From food to medicine: process development and use of functionalized polyclonal antibodies from cow's milk for the treatment of infections caused by multi-resistant bacteria (2019).

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From food to medicine: process development and use of functionalized polyclonal antibodies from cow's milk for the treatment of infections caused by multi-resistant bacteria, Hans-Jürgen Heidebrecht

Jazyk
Rok vydání
2019,
Stav knihy
Dobrá
Cena
109 Kč

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Titul
From food to medicine: process development and use of functionalized polyclonal antibodies from cow's milk for the treatment of infections caused by multi-resistant bacteria
Jazyk
anglicky
Vydavatel
Dr. Hut
Rok vydání
2019
ISBN10
3843942684
ISBN13
9783843942683
Série
Anotace
In this thesis, the process-technical prerequisites were achieved to provide new cow antibody-based therapeutic options for bacterial infections as substitutes for non-specific antibiotics. Microfiltration was investigated for the fractionation of antibodies from milk and a new scalable chromatography process for the isolation of IgG was developed. Specific polyclonal antibodies were induced by immunization of cows in milk, the products obtained were characterized and their efficacy demonstrated for the treatment of Clostridium difficile infection in an animal model.