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Focusing on the therapeutic potential of Au (I, III) complexes, the book investigates their selective inhibition of zinc finger proteins (ZnFs), particularly targeting the HIV-1 nucleocapsid protein and the human transcription factor Sp1. Innovative techniques such as Travelling-Wave Ion Mobility coupled with Mass Spectrometry and X-ray Absorption Spectroscopy are employed to elucidate the coordination sphere of gold adducts. Additionally, the organometallic compound [Au (bnpy)Cl2] is assessed for its ability to inhibit ZnFs through C-S coupling, revealing promising insights for future treatments.
Nákup knihy
Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins, Raphael Enoque Ferraz de Paiva
- Jazyk
- Rok vydání
- 2019
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Doručení
Platební metody
Navrhnout úpravu
- Titul
- Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins
- Jazyk
- anglicky
- Vydavatel
- Springer International Publishing
- Rok vydání
- 2019
- Vazba
- měkká
- Počet stran
- 192
- ISBN13
- 9783030131500
- Kategorie
- Chemie, Příroda všeobecně
- Anotace
- Focusing on the therapeutic potential of Au (I, III) complexes, the book investigates their selective inhibition of zinc finger proteins (ZnFs), particularly targeting the HIV-1 nucleocapsid protein and the human transcription factor Sp1. Innovative techniques such as Travelling-Wave Ion Mobility coupled with Mass Spectrometry and X-ray Absorption Spectroscopy are employed to elucidate the coordination sphere of gold adducts. Additionally, the organometallic compound [Au (bnpy)Cl2] is assessed for its ability to inhibit ZnFs through C-S coupling, revealing promising insights for future treatments.